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Skip to main content. Search SpringerLink Search. Download PDF. Abstract Views on ageing VoA have special relevance for the ageing process by influencing health, well-being, and longevity.
Linking views on ageing to fundamental principles of lifespan development Theories of lifespan development do not generally explicitly address VoA for exceptions, see Heckhausen et al.
VoA are embedded within a greater historical, cultural, and societal context Another cornerstone of lifespan development is recognition of the fact that people are embedded in historical, cultural, and societal contexts which both create and limit their developmental opportunities. VoA are multidimensional, multidirectional, and multifunctional Just as lifespan development consists of both gains and losses in different domains of functioning Baltes et al.
Summing up Given the close links between VoA and the principles of lifespan development, a lifespan approach is not only warranted but inevitable in order to fully understand the content and characteristics of VoA, how VoA develop over ontogenetic time, and how VoA impact development. Views on ageing as both drivers and products of lifespan development.
Full size image. Three core propositions of a lifespan approach to views on ageing To address some of the gaps in existing theories of VoA, we now draw on existing lifespan developmental and VoA theories as well as empirical evidence to elaborate on three core propositions of a lifespan approach to VoA see Table 1 for a summary.
Table 1 Summary of propositions and empirical findings Full size table. Recommendations for future research on VoA Finally, we turn our attention to what is in our opinion still needed to take lifespan research on VoA to the next level. Establish ways to measure and quantify the complexity of VoA We have argued that the complexity of VoA is highly relevant. Understand how VoA are related to other psychological constructs We also need to better understand the distinctiveness of VoA relative to other psychological constructs that are not defined by their age-relatedness but likewise influence developmental regulation, such as control beliefs, self-efficacy, or general optimism.
Gather longitudinal data from lifespan samples Even though several large, longitudinal datasets contain information on age stereotypes, self-perceptions of ageing, or rarely even both, they are usually confined to just middle-aged and older adults. Article 31 Dec Nature Genetics. Article 11 Feb Nature Neuroscience. Brief Communication 27 Apr Nature Neuroscience. Article 29 Apr Nature. Article 2 Mar Nature Medicine. Advanced search. Skip to main content Thank you for visiting nature.
Collection 21 September Aging, longevity and age-related diseases Our understanding of the biology of aging and longevity has grown tremendously over the past two decades. Collection home Collection team.
Bringing together different strands of genetic research, including results from recent large-scale genome-wide association studies relevant to human ageing, the authors highlight how genetics can further our understanding of the underlying mechanisms of ageing. The majority of cancers arise in individuals over the age of This Review discusses how ageing tissues through changes in the extracellular matrix as well as in the functions of fibroblasts and immune cells can impact tumour initiation, progression and response to therapy.
A single-cell transcriptomic atlas across the lifespan of the mouse, denoted Tabula Muris Senis , provides molecular information about the hallmarks of ageing in a range of tissues and cell types. COL17A1-driven stem cell competition and symmetric cell divisions initially govern skin homeostasis, but the same mechanisms result in skin ageing later in life. Dietary restriction DR late in life does not improve survival and has little benefit in metabolic health in mice.
Naked mole rats are the longest-lived rodents and produce very-high-molecular-mass hyaluronan vHMM-HA. Here the authors show that naked mole rat vHMM-HA is better at protecting mouse and human cells from cell cycle arrest and cell death, compared to the high-molecular-mass hyaluronan produced by these species.
PLoS One. Epub Jan Sci Transl Med. Young RD. Validated living worldwide supercentenarians, living and recently deceased: February Rejuvenation Res. Other chapters in Help Me Understand Genetics. Genetics Home Reference has merged with MedlinePlus. Learn more. The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.
Is longevity determined by genetics? From Genetics Home Reference. Topics in the Genetics and Human Traits chapter Are fingerprints determined by genetics? Though this definition of lifespan may seem simple enough, it is often confused with other common concepts in the study of the aging , life, and death of living organisms.
In order to better understand the human lifespan, let's dive a little deeper into the concept and its important distinctions from other commonly used terms. The term lifespan is most commonly confused with another important concept: life expectancy.
While both terms relate to the number of living years, they actually define very different concepts. While the term lifespan refers to the maximum number of years an individual can live, life expectancy refers to an estimate or an average number of years a person can expect to live.
Most simply put, life expectancy can be attributed to and impacted by an individual and their personal health history, genetics, and lifestyle, whereas lifespan holds for all living humans. For example, a person's life expectancy is affected by personal factors like family history, environment , diet, and even age and sex.
One person's life expectancy might be different from your life expectancy and it may even change over time. Your life spans, however, are one in the same. We all share it as members of the same species. So what is the human life span? Given that the human lifespan is defined by the longest observed human life from birth to death, it is a figure that has changed over the years.
For humans, the current accepted maximum lifespan is years. This age was achieved by Jeane Louise Calment of France.
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